HBsAg seroprevalence in students for college entrance examination from 2006 to 2014 in Qidong of Jiangsu Province
10.3969/j.issn.1001-5256.2015.10.033
- VernacularTitle:启东地区2006-2014年高考生血清HBsAg携带状况分析
- Author:
Zhengping NI
1
;
Taoyang CHEN
;
Rong SHEN
Author Information
1. Qidong People′s Hospital/Qidong Liver Cancer Institute, Qidong, Jiangsu 226200, China
- Publication Type:Research Article
- Keywords:
hepatitis B surface antigens；hepatitis B vaccines；adolescent
- From:
Journal of Clinical Hepatology
2015;31(10):1692-1694
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the HBsAg seroprevalence in the young generation in Qidong of Jiangsu Province, China. MethodsA total of 15 534 students for college entrance examination from 2006 to 2014 were randomly selected from three secondary schools in Qidong as student group. Some of them had hepatitis B vaccination at birth. A total of 1208 adults who had their routine checkups in our hospital from 2007 to 2013 were selected as adult group. It was confirmed that all of them did not have hepatitis B vaccination at birth. Serum HBsAg levels of the two groups were measured using enzyme-linked immunosorbent assay and the seroprevalence was analyzed. Comparison of data between the two groups was made by chi-square test. Results In the 9 years from 2007 to 2013, the seroprevalence rates of HBsAg in the student group were 4.2%(75/1794), 4.3%(77/1797), 4.4%(82/1858), 4.3%(82/1903), 3.4%(56/1627), 2.6%(46/1768), 1.6%(29/1778), 1.6%(27/1642), and 1.8%(24/1367), respectively. The mean HBsAg seroprevalence of the student group was 32%(498/15534), significantly lower compared with 7.1% (86/1208) of the adult group (χ2= 59.986, P＜0.001). In both of the student group and the adult group, the males had a significantly higher HBsAg seroprevalence than the females (χ2=10.521, P=0001; χ2=8.452, P=0.004) and the values were 3.7%(266/7236) vs 2.8%(229/8298) and 8.8%(66/750) vs 4.4%(20/458), respectively. Among male subjects, the HBsAg seroprevalence of the adult group was 2.4 times that of the student group; among female subjects, the HBsAg seroprevalence of the adult group was 1.6 times that of the student group. ConclusionIn the recent 9 years from 2006 to 2014, the HBsAg seroprevalence in students for college entrance examination declined continuously. The goal set by the World Health Organization Western Pacific Region in 2010 had been achieved ahead of the schedule that the HBsAg seroprevalence should be controlled below 2% in children aged less than 5.
