Efficacy of adjuvant therapy with fenofibrate for primary biliary cirrhosis: a Meta-analysis
10.3969/j.issn.1001-5256.2015.10.017
- VernacularTitle:非诺贝特辅助治疗原发性胆汁性肝硬化效果的Meta分析
- Author:
Yuan YU
1
;
Zongguo YANG
;
Shishi CHEN
Author Information
1. Shanghai Public Health Clinical Center, Fudan University, Shanghai 200540, China
- Publication Type:Research Article
- Keywords:
liver cirrhosis, biliary;
procetofen;
Meta-analysis
- From:
Journal of Clinical Hepatology
2015;31(10):1630-1633
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo assess the efficacy of adjuvant therapy with fenofibrate for primary biliary cirrhosis (PBC). MethodsCNKI, Wanfang Data, China Biology Medicine, PubMed, Embase, and Cochrane library were searched for the pertinent literature of randomized controlled trials (RCTs) of adjuvant therapy with fenofibrate for PBC published up to December 31, 2014. Data extraction and quality assessment were carried out, and the data were statistically analyzed by Stata10.1 software. Respectively, for heterogeneity test. The fixed effect model is chosen for homogeneity, and the random effect model is chosen for heterogeneity. ResultsSix RCTs met the inclusion criteria. Treatment with fenofibrate was associated with significantly reduced levels of gamma-glutamyl transpeptidase, alanine aminotransferase, and alkaline phosphatase in PBC patients (SMD=-1.595, -0.447, and -2.125, respectively, all P＜0.05). There were no significant changes in the levels of aspartate aminotransferase and total bilirubin after adjuvant therapy with fenofibrate (both P＞0.05). Also, fenofibrate led to no significant improvement in immunoglobulin M (P＞0.05). ConclusionFenofibrate, which improves the indicators of liver function but leads to no changes in immunological indicators, appears to be an effective adjuvant therapy in PBC patients. There is a critical need for more large-scale, multi-center, high-quality RCTs to determine its effect on liver disease-related morbidity and mortality.
