Expression and significance of classical ACE-AngII-AT1 axis and new ACE2-Ang (1-7)-Mas axis of renin-angiotensin system in local pancreas

VernacularTitle:胰腺局部肾素-血管紧张素系统经典轴ACE-AngII -AT1及新轴ACE2-Ang (1-7) -Mas的表达及意义
Author: Xiaoya LIU ¹ ; Ruixia LIU ; Chenghong YIN
Author Information

1. Department of Infection, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China
Publication Type:Research Article
Keywords: pancreas; renin-angiotensin system; angiotensins; pepticly-clipeptidase; review
From: Journal of Clinical Hepatology 2015;31(9):1554-1557
CountryChina
Language:Chinese
Abstract: The renin-angiotensin system (RAS) is a classical circulating enzyme pathway that plays an important role in regulation of pancreatic function. In recent years, with deepening understanding of RAS, researchers found that RAS not only includes the classical ACE-Ang II-AT1 axis, but also includes the new ACE2-Ang (1-7)-Mas axis. Extensive studies have confirmed that the ACE2-Ang (1-7)-Mas axis can antagonize the effect of the ACE-Ang II-AT1 axis. This paper reviews the composition and function of both axes of the RAS in the local pancreas, and also presents the comparison between the two axes.