Role of Wnt signaling pathway in progression of liver cirrhosis
10.3969/j.issn.1001-5256.2015.09.045
- VernacularTitle:Wnt信号通路对肝硬化进展的影响
- Author:
Xueling ZHOU
1
;
Shuiping YU
Author Information
1. The Affiliated Hospital of Guilin Medical University, Guilin, Guangxi 541000, China
- Publication Type:Research Article
- Keywords:
liver cirrhosis;
Wnt proteins;
signal transduction;
review
- From:
Journal of Clinical Hepatology
2015;31(9):1540-1542
- CountryChina
- Language:Chinese
-
Abstract:
In the past, liver cirrhosis was thought to be irreversible. However, theoretically, the process of liver cirrhosis could be slowed down by inhibiting extracellular matrix (ECM) production and by promoting its degradation. Wnt signaling pathway has been involved in many physiological and pathological processes and some studies have confirmed that abnormal activation of Wnt signaling pathway could cause activation of hepatic stellate cells, and then further induce ECM formation and prompt cirrhosis progression. We believe that new clinical therapeutic direction would emerge after in-depth exploration of the mechanism of Wnt signaling pathway involved in liver cirrhosis progression.
