Research advances in therapeutic strategies against covalently closed circular DNA of hepatitis B virus
10.3969/j.issn.1001-5256.2015.09.040
- VernacularTitle:靶向HBV共价闭合环状DNA的治疗策略
- Author:
Qiang LI
1
;
Qibin ZHUO
;
Yuxian HUANG
Author Information
1. First Department of Hepatitis, Public Health Clinical Center Affiliated to Fudan University, Shanghai 201508, China
- Publication Type:Research Article
- Keywords:
hepatitis B virus;
DNA, circular;
targeted therapy;
review
- From:
Journal of Clinical Hepatology
2015;31(9):1520-1523
- CountryChina
- Language:Chinese
-
Abstract:
Chronic infection with hepatitis B virus (HBV) often leads to the development of liver cirrhosis and liver cancer, creating immense sociological, clinical, and economic burdens worldwide. Although current anti-HBV drugs can control the disease progression, they often fail to eliminate the virus because of the presence of covalently closed circular DNA (cccDNA) in the hepatocyte nucleus. We review the research advances in therapeutic strategies against cccDNA from the aspects of interfering with cccDNA synthesis, promoting cccDNA degradation, and silencing cccDNA. Targeting cccDNA is a promising approach that may lead to a cure of chronic HBV infection.
