Clinical characteristics of autoimmune hepatitis: an analysis of 194 patients
10.3969/j.issn.1001-5256.2015.09.026
- VernacularTitle:194例自身免疫性肝炎患者的临床特征分析
- Author:
Yongjun DENG
1
;
Minzhong XIAO
;
Xiaodong LI
Author Information
1. Department of Clinical Laboratory, Guanggu Branch of Hubei Provincial Hospital of Traditional Chinese Medicine, Wuhan 430074, China)
- Publication Type:Research Article
- Keywords:
hepatitis, autoimmune;
autoantibody;
clinical chemistry tests;
pathology, clinical
- From:
Journal of Clinical Hepatology
2015;31(9):1473-1476
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the main clinical characteristics of patients with autoimmune hepatitis (AIH). MethodsAn analysis was performed on the data of 194 AIH patients who visited Guanggu Branch of Hubei Provincial Hospital of Traditional Chinese Medicine from December 2010 to December 2014 and 197 healthy blood donors who served as control group. Autoantibodies, biochemical indicators, and liver biopsy were evaluated for AIH patients. The type of AIH patients was determined according to the results of test of autoantibodies and a statistical analysis was conducted for age, sex, biochemical markers, and pathological manifestations of all the AIH patients, Comparison of continuous data between groups was made by analysis of variance and comparison of categorical data between groups was made by chi-square test. ResultsThe female/male ratio was 154∶40 among the 194 AIH patients. The morbidity achieved a peak value among the patients aged 40-60 years. The proportion of the patients older than 40 years were 76.80% (149/194). According to the results of test of autoantibodies, the numbers of type-Ⅰ, -Ⅱ, and -Ⅲ AIH patients were 163, 5, and 26, respectively, the female/male ratios were 131∶32, 4∶1, and 19∶7, respectively, and the mean ages were 59.26±10.24, 16.54±8.21, and 63.38±12.92 years, respectively. There were significant differences in alanine aminotransferase, aspartate aminotransferase, gamma-glutamyltransferase, and immunoglobulin G between type-Ⅰ AIH patients and type-Ⅱ and -Ⅲ AIH patients (all P＜0.05), and immunoglobulin A significantly differed between type-Ⅱ AIH patients and type-Ⅰ and -Ⅲ AIH patients (P＜0.05). Pathological manifestations of AIH showed interface hepatitis, infiltration of lymphocytes and plasma cells, and rosette-like changes. ConclusionAIH patients are mostly female aged 40-60 years. The peak age of onset ranges from 40 to 60 years. Biochemical indicators have various degrees of increase among type-Ⅰ, -Ⅱ, and -Ⅲ AIH patients. The main pathological manifestation is interface hepatitis.
