Transmission of Seasonal Outbreak of Childhood Enteroviral Aseptic Meningitis and Hand-foot-mouth Disease.
10.3346/jkms.2010.25.5.677
- Author:
Sue K PARK
1
;
Boyoung PARK
;
Moran KI
;
Ho KIM
;
Kwan LEE
;
Cheoll JUNG
;
Young Mo SOHN
;
Sung Min CHOI
;
Doo Kwun KIM
;
Dong Seok LEE
;
Joon Tae KO
;
Moon Kyu KIM
;
Hae Kwan CHEONG
Author Information
1. Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea.
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Meningitis, Aseptic;
Hand, Foot and Mouth Disease;
Disease Transmission;
Waterborne Infection;
Enterovirus;
Epidemiology
- MeSH:
Adolescent;
Child;
Child, Preschool;
Comorbidity;
Disease Outbreaks/*statistics & numerical data;
Enterovirus Infections/*epidemiology/*transmission;
Female;
Hand, Foot and Mouth Disease/*epidemiology/*transmission;
Humans;
Incidence;
Male;
Meningitis, Aseptic/*epidemiology;
Risk Assessment;
Risk Factors;
*Seasons
- From:Journal of Korean Medical Science
2010;25(5):677-683
- CountryRepublic of Korea
- Language:English
-
Abstract:
This study was conducted to evaluate the modes of transmission of aseptic meningitis (AM) and hand-foot-mouth disease (HFMD) using a case-control and a case-crossover design. We recruited 205 childhood AM and 116 HFMD cases and 170 non-enteroviral disease controls from three general hospitals in Gyeongju, Pohang, and Seoul between May and August in both 2002 and 2003. For the case-crossover design, we established the hazard and non-hazard periods as week one and week four before admission, respectively. In the case-control design, drinking water that had not been boiled, not using a water purifier, changes in water quality, and contact with AM patients were significantly associated with the risk of AM (odds ratio [OR]=2.8, 2.9, 4.6, and 10.9, respectively), while drinking water that had not been boiled, having a non-water closet toilet, changes in water quality, and contact with HFMD patients were associated with risk of HFMD (OR=3.3, 2.8, 6.9, and 5.0, respectively). In the case-crossover design, many life-style variables such as contact with AM or HFMD patients, visiting a hospital, changes in water quality, presence of a skin wound, eating out, and going shopping were significantly associated with the risk of AM (OR=18.0, 7.0, 8.0, 2.2, 22.3, and 3.0, respectively) and HFMD (OR=9.0, 37.0, 11.0, 12.0, 37.0, and 5.0, respectively). Our findings suggest that person-to-person contact and contaminated water could be the principal modes of transmission of AM and HFMD.
