Improvement in liver function in patients with malignant obstructive jaundice after endoscopic biliary metallic stent drainage
10.3969/j.issn.1001-5256.2015.08.027
- VernacularTitle:胆道支架引流术对恶性梗阻性黄疸患者术后肝功能的影响
- Author:
Wenjun WANG
1
;
Conghui YU
Author Information
1. Second Clinical Medical College of Shanxi Medical University, Taiyuan 030001, China
- Publication Type:Research Article
- Keywords:
jaundice, obstructive;
stents;
drainage
- From:
Journal of Clinical Hepatology
2015;31(8):1295-1298
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo explore the clinical efficacy of endoscopic biliary metallic stent drainage (EBMSD) in the treatment of malignant obstructive jaundice (MOJ). MethodsA total of 48 patients with MOJ who underwent EBMSD in the General Hospital of Beijing Military Command from January 2012 to April 2014 were included in the study. Liver function parameters, including alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), total bilirubin (TBil), direct bilirubin (DBil), and glutamyl transpeptidase (GGT), were compared before and after treatment. Comparison of continuous data was made by t test. ResultsPlacement of the stent was successfully performed in 44 (91.67%) of the 48 patients; single-stent drainage was performed in 34 cases, and double-stent drainage in 10 cases. The patients had significantly reduced levels of TBil, DBil, ALT, AST, ALP, and GGT after EBMSD (all P＜0.01); the patients treated by double-stent drainage had significantly more improvements in these liver function indices than those treated by single-stent drainage (all P＜0.01). Thirty-eight cases were successfully followed up after operation, and the 3- and 6-month survival rates of these patients were 94.25% and 73.39%, respectively. ConclusionEBMSD has remarkable efficacy in the treatment of MOJ. This operation can effectively relieve jaundice and improve quality of life in MOJ patients, and double-stent drainage is superior to single-stent drainage.
