Analysis of factors influencing hepatitis C with thyroid dysfunction in Chinese patients
10.3969/j.issn.1001-5256.2015.08.020
- VernacularTitle:中国慢性丙型肝炎患者合并甲状腺功能异常的影响因素调查
- Author:
Ni JIANG
1
;
Xiaorong MAO
;
Xuebin PENG
Author Information
1. Institute of Infectious Diseases, The First Hospital of Lanzhou University, Lanzhou 730000, China
- Publication Type:Research Article
- Keywords:
hepatitis C, chronic;
thyroid diseases;
epidemiologic factors;
China
- From:
Journal of Clinical Hepatology
2015;31(8):1266-1270
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo explore the influencing factors for chronic hepatitis C (CHC) with thyroid dysfunction (TD) in untreated Chinese patients and provide evidence for clinical individualized treatment. MethodsOne thousand and twelve untreated CHC patients were collected nationwide in China. Thyroid function and associated influencing factors (region, age, gender, and hepatitis C virus (HCV) RNA replication level) in the patients were investigated. The relationships between the influencing factors and CHC with TD were analyzed. Between-group comparison of categorical data was performed by χ2 test and Fisher′s exact test. ResultsThere were geographical differences between different types of CHC with TD. Across different regions, the incidence of TD was highest in north and northwest China, i.e., 28.3% and 26.5%, respectively. Subclinical hypothyroidism was the most common type of TD, accounting for 58.8% of the total TD cases. Middle-aged patients were most common among the cases of CHC with TD (44.0%), who had a significantly higher incidence of hypothyroidism than other age groups (χ2=1010、617, P=0.001、0013). Females with CHC had a significantly higher incidence of TD than male patients (58.9% vs. 41.1%, χ2=13.1, P=0.00). Although a high HCV RNA replication level was most common in Chinese patients with CHC, this factor had little influence on TD. ConclusionIn China, CHC with TD is influenced by geographic distribution, gender, and age, but less associated with HCV RNA replication level.
