Relationship of intestinal microecology with infantile cholestatic liver disease
10.3969/j.issn.1001-5256.2015.08.010
- VernacularTitle:肠道微生态与婴儿胆汁淤积性肝病的关系
- Author:
Xiaoli PANG
1
;
Zhaoxi WANG
Author Information
1. Department of Pediatric Gastroenterology, The First Hospital of Jilin University, Changchun 130021, China
- Publication Type:Research Article
- Keywords:
cholestasis, intrahepatic;
intestinal microecology;
infant
- From:
Journal of Clinical Hepatology
2015;31(8):1221-1225
- CountryChina
- Language:Chinese
-
Abstract:
Intestinal microecology is an important and complex biological system essential to human health. Intestinal microecology and the liver are closely related in anatomical structure and function. Infantile cholestatic liver disease lead to abnormal bile secretion, abnormal excretion, and reduced bile release into the intestinal tract. As a result, the intestinal mucosa barrier is damaged and intestinal microecology changes; at the same time, pathogenic bacteria and endotoxin translocation cause liver injury and aggravate cholestasis. Therefore, a close relationship of intestinal microecology with infantile cholestatic liver disease can be found. In this article, the relationship of intestinal microecology with the development and progression of infantile cholestatic liver disease is illustrated and it is concluded that probiotics should be given as a supplement when infantile cholestatic liver disease occurs, because it promotes bile secretion, blocks intestinal inflammatory reactions, and improves prognosis of the disease. It is recommended to provide microecological agents routinely as a method to prevent and treat infantile cholestatic liver disease.
