Antiviral therapy of chronic hepatitis B in children

VernacularTitle:儿童慢性乙型肝炎的抗病毒治疗
Author: Shishu ZHU ¹ ; Hongfei ZHANG
Author Information

1. Pediatric Liver Disease Therapy and Research Center, 302 Hospital of PLA, Beijing 100039, China
Publication Type:Research Article
Keywords: hepatitis B, chronic; child; therapy
From: Journal of Clinical Hepatology 2015;31(8):1211-1214
CountryChina
Language:Chinese
Abstract: For children with chronic hepatitis B (CHB), the antiviral therapy should be started in the immune active phase. There are two categories of antiviral drugs used for CHB: interferons (IFNs) and nucleos(t)ide analogues (NAs). In this paper, the current status of antiviral therapy of CHB in children is reviewed. It is pointed out that IFNs are the drug of first choice in antiviral therapy for children with CHB, and the individualized treatment and management of adverse events need to be considered. Some NAs can be given to those special children who cannot accept IFNs. However, there is a high risk of relapse after drug withdrawal. And the subsequent treatment will be seriously affected once the drug resistance is developed. It needs further investigation to improve the efficacy of antiviral therapy and reduce the adverse events and the drug resistance in the future.