Application of tumor necrosis factor antagonists in hepatic disease treatment
10.3969/j.issn.1001-5256.2015.07.045
- VernacularTitle:肿瘤坏死因子拮抗剂在肝病治疗中的应用
- Author:
Zhaochun CHI
1
;
Changxin GENG
Author Information
1. Department of Gastroenterology, Qingdao Municipal Hospital, Affiliated Hospital of College of Pharmacy, Ocean University of China, Qingdao, Shandong 266071, China
- Publication Type:Research Article
- Keywords:
liver cliseases;
tumor necrosis factor-alpha;
review
- From:
Journal of Clinical Hepatology
2015;31(7):1176-1178
- CountryChina
- Language:Chinese
-
Abstract:
All tumor necrosis factor (TNF) antagonists are associated with hepatotoxicity and thus induce liver injury, commonly manifested as hepatitis B virus and hepatitis C virus reactivation, acute hepatitis, drug-induced liver disease, cholestasis, serum liver enzyme activity elevation, and even acute liver failure. Hence, the application of TNF antagonists in hepatic disease treatment remains controversial. This review summarizes currently available data on the mechanism and application of TNF antagonists in hepatic disease treatment. Although TNF antagonists have been applied for many years, large randomized controlled trials are still recommended to assess its efficacy and safety and to achieve a consensus.
