Research progress in role of myosin light chain kinase in pathogenesis of nonalcoholic fatty liver disease
10.3969/j.issn.1001-5256.2015.07.040
- VernacularTitle:肌球蛋白轻链激酶在非酒精性脂肪性肝病发病机制中的作用
- Author:
Chunmiao LI
1
;
Liwei ZHUANG
Author Information
1. The Fourth Hospital of Harbin Medical University, Harbin 150000, China
- Publication Type:Research Article
- Keywords:
fatty liver;
myosin-light-chain kinase;
pathologic processes;
review
- From:
Journal of Clinical Hepatology
2015;31(7):1156-1159
- CountryChina
- Language:Chinese
-
Abstract:
Myosin light chain kinase (MLCK) is a key enzyme involved in intestinal mucosal mechanical barrier and plays an important role in the pathogenesis of nonalcoholic fatty liver disease (NAFLD). This article describes the "two-hit theory" for NAFLD and gut-derived endotoxin which plays a major role in the pathogenesis of NAFLD, the relationship between endotoxin, MLCK, and NAFLD, and the impact of MLCK inhibitor ML-7 on the intestinal barrier. MLCK inhibitor ML-7 may hinder and delay the development and progression of NAFLD, providing a novel clinical idea for the early prevention of NAFLD.
