Role of Toll-like receptors in development and progression of nonalcoholic fatty liver disease
10.3969/j.issn.1001-5256.2015.07.039
- VernacularTitle:Toll样受体在非酒精性脂肪性肝病发生发展中的作用
- Author:
Jie CHEN
1
;
Jing ZHANG
;
Qiushui HE
Author Information
1. Department of Toxic Hepatopathy, Beijing Youan Hospital Affiliated to Capital Medical University, Beijing 100069, China
- Publication Type:Research Article
- Keywords:
fatty liver;
Toll-like receptors;
review
- From:
Journal of Clinical Hepatology
2015;31(7):1153-1155
- CountryChina
- Language:Chinese
-
Abstract:
The pathogenesis of nonalcoholic fatty liver disease (NAFLD) remains unclear. Many studies have shown that Toll-like receptors are involved in the development and progression of NAFLD, especially nonalcoholic steatohepatitis. This article reviews the role of Toll-like receptors in the pathogenesis of NAFLD from three aspects: interactions between Toll-like receptors and inflammatory factors, interactions between Toll-like receptors and free fatty acids, and Toll-like receptor gene polymorphism.
