Effects of Combined Therapy with Ezetimibe Plus Simvastatin After Drug-Eluting Stent Implantation in a Porcine Coronary Restenosis Model.
10.3346/jkms.2010.25.5.716
- Author:
Jung Sun CHO
1
;
Myung Ho JEONG
;
Doo Sun SIM
;
Young Joon HONG
;
Kyung Seob LIM
;
Jung Ha KIM
;
Hyoung Doo KIM
;
Ju Yeal BAEK
;
Hee Jeoung YOON
;
Sung Ho HER
;
Seung Won JIN
;
Ju Han KIM
;
Youngkeun AHN
;
Jeong Gwan CHO
;
Jong Chun PARK
;
Jung Chaee KANG
Author Information
1. Department of Internal Medicine, The Catholic University of Korea College of Medicine, Seoul, Korea.
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Stents;
Restenosis;
Inflammation;
Endothelization
- MeSH:
Animals;
Anticholesteremic Agents/administration & dosage;
Azetidines/*administration & dosage;
Coronary Restenosis/diagnosis/drug therapy/*etiology;
*Disease Models, Animal;
Drug Combinations;
Drug Implants/administration & dosage;
Drug-Eluting Stents/*adverse effects;
Female;
Graft Occlusion, Vascular/diagnosis/*drug therapy/*etiology;
Humans;
Hydroxymethylglutaryl-CoA Reductase Inhibitors/administration & dosage;
Simvastatin/*administration & dosage;
Swine;
Treatment Outcome
- From:Journal of Korean Medical Science
2010;25(5):716-722
- CountryRepublic of Korea
- Language:English
-
Abstract:
The aim of this study was to examine the anti-proliferative and anti-inflammatory effects of ezetimibe/simvastatin (E/S) after drug-eluting stent (DES) implantation in a porcine coronary restenosis model. Pigs were randomized into two groups in which the coronary arteries (23 pigs) had DES. Stents were deployed with oversizing (stent/artery ratio 1.3:1) in porcine coronary arteries. Fifteen pigs were taken 10/20 mg of E/S and eight pigs were not taken E/S. Histopathologic analysis was assessed at 28 days after stenting. In neointima, most inflammatory cells were lymphohistiocytes. Lymphohistiocyte count was not different between two groups (337+/-227 vs. 443+/-366 cells, P=0.292), but neointima area was significantly smaller (1.00+/-0.49 mm2 vs. 1.69+/-0.98 mm2, P=0.021) and percent area stenosis was significantly lower (23.3+/-10% vs. 39+/-19%, P=0.007) in E/S group compared with control group. There were no significant differences in fibrin score (1.99+/-0.79 vs. 1.81+/-0.88, P=0.49), endothelial score (1.75+/-0.66 vs. 1.80+/-0.59, P=0.79), and the percent of endothelium covered lumen (43+/-21% vs. 45+/-21%, P=0.84) between E/S group and control group. Combined therapy with ezetimibe and simvastatin inhibits neointimal hyperplasia, but does not inhibit inflammatory infiltration and arterial healing after DES implantation in a porcine coronary restenosis model.
