Diagnosis and treatment of hepatocellular carcinoma from a new perspective of miRNAs
10.3969/j.issn.1001-5256.2015.06.037
- VernacularTitle:从微小RNAs看肝细胞癌诊治新视点
- Author:
Qiang LI
1
;
Qibin ZHUO
;
Yuxian HUANG
Author Information
1. First Department of Hepatitis, Shanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China
- Publication Type:Research Article
- Keywords:
carcinoma, hepatocellular;
microRNAs;
early diagnosis;
treatment;
review
- From:
Journal of Clinical Hepatology
2015;31(6):977-
- CountryChina
- Language:Chinese
-
Abstract:
The hepatocellular carcinoma (HCC) diagnosed by serum biomarkers is usually at late stages, and the five-year survival rate of HCC is extremely low. Therefore, it is necessary to develop an efficient and noninvasive biomarker that can detect HCC at an early stage and to explore a new strategy for the treatment of HCC. Abundant evidence has shown that microRNAs(miRNA)s is involved in the development and progression of HCC, and it can be a sensitive biomarker for the detection of HCC and a new target for the treatment of HCC. The article introduces the application of miRNAs in the diagnosis and treatment of HCC, and believes that the diagnosis and treatment strategy for HCC based on miRNAs has great potential in clinical application, yet remains to be studied.
