Hepatic stellate cells, Toll-like receptor 4 signaling pathway, and inflammatory fibrotic microenvironment in the development of hepatocellular carcinoma
10.3969/j.issn.1001-5256.2015.06.012
- VernacularTitle:肝星状细胞、Toll样受体4信号途径、炎症及纤维化微环境与原发性肝癌发生发展的关系
- Author:
Yujing WU
1
;
Jinsheng GUO
Author Information
1. Department of Gastroenterology, Zhongshan Hospital, Fudan University, Shanghai 200032, China
- Publication Type:Research Article
- Keywords:
carcinoma, hepatocellular;
liver cirrhosis;
cytokines;
inflammation;
Toll-like receptor 4
- From:
Journal of Clinical Hepatology
2015;31(6):876-
- CountryChina
- Language:Chinese
-
Abstract:
The development of hepatocellular carcinoma (HCC) is closely related to the precancerous microenvironment of inflammation and fibrosis. The activated hepatic stellate cells (HSCs) are the major source of extracellular matrix in the development of liver fibrosis and the key effective cells of hepatic inflammatory responses. HSCs have an intact Toll-like receptor 4 (TLR4) signaling pathway, which mediates important biological properties of HSCs such as fibrogenesis, inflammatory phenotype, and immunoregulatory function. The TLR4 signaling pathway is involved in the development and progression of chronic liver diseases, and mediates liver fibrogenesis and HCC. HSCs produce several cytokines and growth factors by TLR4 signaling pathway, which has been confirmed to be related to the development of HCC.
