New advances in pharmacological mechanism of silymarin and re-investigation of its clinical values
10.3969/j.issn.1001-5256.2015.02.044
- VernacularTitle:水飞蓟素药理机制新进展及临床价值再探讨
- Author:
Qingquan LI
1
;
Qiang ZHOU
;
Junqi NIU
Author Information
1. Department of Hepatology, The First Hospital of Jilin University, Changchun 130021, China
- Publication Type:Research Article
- Keywords:
silymarin;
molecular mechnisms of pharmacological action;
liver;
pancreas;
review
- From:
Journal of Clinical Hepatology
2015;31(2):315-
- CountryChina
- Language:Chinese
-
Abstract:
Silymarin is a traditional hepatoprotective herb for the adjuvant therapy of liver diseases, which shows marked pharmacological activities such as antioxidant and anti-inflammatory properties. This paper introduces the action mechanism of silymarin in regulating liver function, ameliorating hepatic fibrosis, protecting pancreatic cells, suppressing the growth of tumor cells, and inhibiting the replication of hepatitis C virus. Silymarin is considered to be a natural medicine with little toxic or side effect at a high dose. It holds promise for anti-tumor, antioxidant, anti-inflammatory, and antiviral application.
