Significance of factor II G20210A mutation in Budd-Chiari syndrome and portal vein thrombosis

VernacularTitle:凝血因子ⅡG20210A突变在布加综合征和门静脉血栓形成中的意义
Author: Wenwen ZHANG ¹ ; Xingshun QI ; Xiaozhong GUO
Author Information

1. Department of Gastroenterology, Shenyang General Hospital of PLA, Shenyang 110016, China
Publication Type:Research Article
Keywords: Budd-Chiari syndrome; portal vein; venous thrombosis; prothrombin; mutation; review
From: Journal of Clinical Hepatology 2015;31(2):310-
CountryChina
Language:Chinese
Abstract: Budd-Chiari syndrome (BCS) is characterized by the hepatic outflow obstruction from the small hepatic vein to the superior hepatic inferior vena cava. Portal vein thrombosis (PVT) refers to the development of thrombosis in the main portal vein, with or without thrombosis in the superior mesenteric or splenic vein. A large number of studies have shown that prothrombin (factor II, F2) G20210A mutation is related to BCS and PVT. F2 and its G20210A mutation are introduced, the effect of F2 G20210A mutation on thrombosis is reviewed, and the prevalence of F2 G20210A mutation in China is analyzed. An attempt is made to focus on the association of F2 G20210A mutation with PVT and BCS. It is believed that F2 G20210A mutation to some extent increases the risk for PVT and BCS. However, the prevalence of F2 G20210A mutation is extremely low in the Chinese population. Thus, this mutation may not be regarded as the cause of PVT and BCS in China.