Association of ERα-29 gene polymorphisms with susceptibility to HBV-related hepatocellular carcinoma
10.3969/j.issn.1001-5256.2015.02.023
- VernacularTitle:雌激素受体α-29位基因多态性与HBV相关原发性肝癌易感性的关系
- Author:
Ning ZHOU
1
;
Yuerong ZHANG
;
Shifang WEI
Author Information
1. Department of Infectious Diseases, The First People's Hospital of Lanzhou, Lanzhou 730050, China
- Publication Type:Research Article
- Keywords:
liver neoplasms;
receptors, estrogen;
polymorphisms, single nucleotide;
polymorphism, restriction fragment length
- From:
Journal of Clinical Hepatology
2015;31(2):240-
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo evaluate the relationship between estrogen receptor-α-29 (ERα-29) gene polymorphisms and the development of HBV-related hepatocellular carcinoma (HCC) in Gansu Province, China, and to investigate the pathogenesis of HCC at the gene level. MethodsGene polymorphisms of ERα-29 were analyzed in 106 HBV-related HCC patients and 98 healthy individuals as normal controls using the polymerase chain reaction-restriction fragment length polymorphism technique. Population allele frequencies were calculated using the gene counting method and then tested using the Hardy-Weinberg law of genetic equilibrium. Comparisons of genotype and allele frequencies between groups were performed using the χ2 test. ResultsThe frequencies of TT genotype and T allele of ERα-29 gene in HBV-related HCC patients were significantly higher than those in the normal controls, i.e., 31.1% and 53.8% vs. 11.2% and 32.1% (χ2 = 3.449, P＜0.05; χ2 = 3.840, P＜0.05). In contrast, the frequencies of CC genotype and C allele of ERα-29 gene in HBV-related HCC patients were significantly lower than those in the normal controls, i.e., 23.6% and 46.2% vs. 47.0% and 67.9% (χ2 = 3.488, P＜0.05; χ2 = 3.840, P＜0.05). Compared with those carrying C allele, carriers of T allele had an increased risk (2.46-fold) of HBV-related HCC (OR = 2.46, 95% CI: 1.64-3.69). Conclusion T allele of ERα-29 gene can increase the risk of HBV-related HCC.
