The Prognostic Value of CA19-9 in Patients with Colorectal Cancer.
- Author:
Min Soo KIM
1
;
Ho Min JOO
;
Seong Wo HONG
;
Yun Kyung KANG
;
Jung Woo CHUN
;
Yeo Goo CHANG
;
In Wook PAIK
;
Hyucksang LEE
Author Information
1. Department of Surgery, Seoul Paik Hospital, Inje University College of Medicine, Seoul, Korea. cosmo021@hanmail.net
- Publication Type:Original Article
- Keywords:
Colorectal cancer;
CA19-9 expression;
Immunohistochemical stain;
Clinicopathologic feature;
Prognostic indicator
- MeSH:
Cell Differentiation;
Colorectal Neoplasms;
Humans;
Lymph Nodes;
Multivariate Analysis;
Neoplasm Metastasis;
Prognosis
- From:Journal of the Korean Surgical Society
2008;75(5):307-314
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: There has been much debate about the significance of the CA19-9 level for predicting the prognosis of colorectal cancer patients. This study aimed to evaluate the prognostic value of the preoperative serum CA19-9 level and the CA19-9 expression in the tumor tissues of colorectal cancer patients METHODS: One hundred patients with colorectal cancer and who had been treated by resection were studied. We assessed the correlations of the preoperative serum CA19-9 level and the status of the CA19-9 immunohistochemical staining with the clinicopathologic features, including the prognosis of the patients. RESULTS: The preoperative serum CA19-9 level had significant correlation with the status of CA19-9 immunohistochemical staining. The presence of distant metastasis was significantly correlated with an elevated level of serum CA19-9. The depth of tumor, the presence of lymph node metastasis, the TNM stage and tumor cell differentiation were significantly correlated with the status of the CA19-9 immunohistochemical staining. In addition, the gross morphology, depth of tumor, the presence of lymph node metastasis, the TNM stage, the status of the CA19-9 immunohistochemical staining and the serum CEA level were correlated with survival on univariate analysis. However, multivariate analysis did not validate the status of CA19-9 immunohistochemical staining as a significantly independent predictor of the prognosis. CONCLUSION: The CA19-9 expression was frequently observed in advanced stage tumor tissue, yet its expression in tumor tissue or the preoperative CA19-9 serum level did not show independent prognostic value for colorectal cancer patients.
