Relationship between intestinal microflora imbalance and nonalcoholic fatty liver disease
10.3969/j.issn.1001-5256.2015.01.029
- VernacularTitle:肠道微生态失衡与非酒精性脂肪性肝病的关系
- Author:
Ruijuan MA
1
;
Jing WU
;
Yongning ZHOU
Author Information
1. Department of Gastroenterology, The First Hospital of Lanzhou University, Lanzhou 730000, China
- Publication Type:Research Article
- Keywords:
intestinal microflora;
fatty liver;
endotoxemia;
inflammation;
review
- From:
Journal of Clinical Hepatology
2015;31(1):127-
- CountryChina
- Language:Chinese
-
Abstract:
The intestinal microecosystem is composed of natural microflora, intestinal epithelial cells, and intestinal mucosal immune system. Nonalcoholic fatty liver disease (NAFLD) is a metabolic stress-induced liver injury associated with insulin resistance and genetic susceptibility. In recent years, there has been increasing evidence showing the involvement of imbalanced intestinal microflora in the pathogenesis of NAFLD. Overgrowth of intestinal microflora, increased permeability of intestinal mucosa, intestinal endotoxemia, and production of inflammatory cytokines play important roles in the development of NAFLD. Further studies on the relationship between intestinal microflora imbalance and the pathogenesis of NAFLD may shed light on the treatment and prevention of NAFLD.
