HCV culture system and its application in antiviral research on Chinese herb extracts in vitro
10.3969/j.issn.1001-5256.2015.01.026
- VernacularTitle:HCV细胞培养系统及其在中草药提取物抗HCV研究中的应用
- Author:
Jingtao LI
1
;
Zhanjie CHANG
;
Qi XI
Author Information
1. The Hospital Affiliated to Shanxi University of TCM, Xianyang, Shanxi 712000, China
- Publication Type:Research Article
- Keywords:
hepatitis C, chronic;
hepacivirus;
drug, Chinese herbal;
cell culture techniques;
replicon;
review
- From:
Journal of Clinical Hepatology
2015;31(1):115-
- CountryChina
- Language:Chinese
-
Abstract:
Many studies have shown that Chinese herb extracts could treat patients who suffer hepatitis C. However, the clinical efficacy is limited due to the use of traditional Chinese medicine (TCM) compounds. Because each drug contains multiple active substances, some of which may even act against each other in vivo, it is hard to clarify the mechanism of treatment. The current research on pseudotyped hepatitis C virus (HCV), replicon, and cell culture system is summarized, and the advances in antiviral research on the monomers or active components of Chinese herbs in vitro based on HCV RNA models are reviewed, thus providing new ideas for TCM treatment of hepatitis C.
