Relationship between hyperuricemia and chronic kidney disease in adult residents of communities in the Songjiang district, Shanghai
10.16462/j.cnki.zhjbkz.2019.03.007
- Author:
Xiao-yan ZHOU
1
;
Qi ZHAO
;
Na WANG
;
Rui-ping WANG
;
Yue ZHANG
;
Yu-ting YU
;
Yong-gen JIANG
;
Gen-ming ZHAO
Author Information
1. Department of Epidemiology, School of Public Health, Fudan University, Shanghai 200032, China
- Publication Type:Research Article
- Keywords:
Uric acid;
Hyperuricemia;
Chronic kidney disease;
Cross-sectional study
- From:
Chinese Journal of Disease Control & Prevention
2019;23(3):278-282,293
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationships between hyperuricemia (HUA)，serum uric acid (SUA) level and the chronic kidney disease (CKD) in adult residents of communities. Methods A cross-sectional study was conducted in Xinqiao town of Songjiang district, Shanghai and a total of 9 527 residents aged 20-75 years were selected by random cluster sampling. Logistic regression models were used to evaluate the association between SUA and CKD. Results Subjects were divided into five groups according to the gender-specific quintiles of SUA. The CKD prevalence in serum uric acid quintiles of male were 4.9%, 5.7%, 6.0%, 8.0% and 13.8% respectively，while of female were 12.8%, 12.7%, 11.9%, 13.3% and 18.2% respectively, increasing along with the increase of SUA among both sexes (all P<0.05). Compared to the serum uric acid first quintile, the multivariate-adjusted odds for CKD in male of the fourth and fifth quintiles were 2.12 (95% CI:1.32-3.39) and 3.84 (95% CI:2.45-6.02), and the multivariate-adjusted odds for CKD in female of the fifth quintile was 1.38 (95% CI:1.05-1.80). Hyperuricemia was defined by SUA>420 μmol/L(male) or >360 μmol/L(female). In the unadjusted model, HUA was significantly associated with CKD of all subjects (OR=2.03, 95% CI:1.69-2.44, P<0.001), and the association was still significant (OR=2.04, 95% CI:1.68-2.49, P<0.001) after adjustment for the potential confounders. The multivariate-adjusted odds of CKD associated with HUA was 2.89 (95% CI:2.12-3.94,) and 1.98 (95% CI:1.51-2.60) for male and female, respectively. Conclusion Hyperuricemia was independently associated with the increased prevalence of CKD among community-based population living in the Songjiang district, Shanghai.
