Relationship between genetic polymorphisms of IL-10 promoter and antituberculosis drug-induced liver injury
10.16462/j.cnki.zhjbkz.2019.01.012
- Author:
Biao LI
1
;
Hua-wen KONG
;
Yu-hong LI
;
Ying DU
;
Ying-zhi CHONG
;
Qi REN
;
Guo-ying ZHENG
;
Fu-min FENG
Author Information
1. Department of Epidemiology and Health Statistics, School of Public Health, North China University of Science and Technology, Tangshan 063210, China
- Publication Type:Journal Article
- Keywords:
IL-10;
Gene Polymorphism;
Antituberculosis drug;
Liver injury
- From:
Chinese Journal of Disease Control & Prevention
2019;23(1):56-59,74
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between interleukin 10 (IL-10) -592 (rs1800872) and -819 (rs1800871) promoter genetic polymorphisms and the susceptibility of antituberculosis drug-induced liver injury (ADLI). Methods A case-control study was conducted. Epidemiology survey data and peripheral blood samples were obtained from the patients. Two IL-10 gene polymorphisms (-592 A/C and 819 C/T) were genotyped with PCR-RFLP (polymerase chain reaction-restriction fragment length polymorphism) in Chinese Han ADLI subjects (n=180) and sex matched by frequency matching in control subjects (n=180). Results No significant differences in genotypes of IL-10 -592 site and IL-10 -819 site between ADLI group and that of the control group were noticed (all P>0.05). The mutant alleles -592 C of IL-10 gene polymorphism was significantly higher in ADLI subjects compared to controls, and in dominant model, the frequency of CC+AC genotype was 1.62 higher among the cases than controls (all P<0.05). Significant difference in allele -819 C/T between the ADLI group and the control group were not found (P=0.190). The polymorphisms at -819 C/T and -592 A/C variants of IL-10 gene were found to be good linkage disequilibrium. The CC haplotype represent genetic risk factor (OR=1.37, 95% CI: 1.02-1.85) and CA haplotype represent genetic protect factor (OR=0.49, 95% CI: 0.34-0.70) for ADLI in the subjects. Conclusions The polymorphisms in IL-10 gene -592 A/C and -819 C/T are associated with ADLI.
