Research advances in the diagnosis and treatment of acute-on-chronic liver failure with infection
10.3969/j.issn.1001-5256.2019.11.046
- VernacularTitle:慢加急性肝衰竭合并感染的诊治
- Author:
Aiqi LU
1
;
Keli YANG
;
Yujuan GUAN
Author Information
1. Department of Hepatology, Guangzhou Eighth People’s Hospital Affiliated to Guangzhou Medical University, Guangzhou 510060, China
- Publication Type:Research Article
- Keywords:
acute-on-chronic liver failure;
bacterial infections and mycoses;
diagnosis;
therapeutics
- From:
Journal of Clinical Hepatology
2019;35(11):2596-2599
- CountryChina
- Language:Chinese
-
Abstract:
Acute-on-chronic liver failure (ACLF) is a severe syndrome of liver diseases commonly seen in clinical practice and can lead to severe disorders and decompensation of liver synthesis, metabolism, detoxification, and biotransformation, as well as multiple organ failure and an extremely high short-term mortality rate. Infection can induce or aggravate the condition of ACLF and is an independent influencing factor for patient prognosis. This article describes the mechanism and characteristics of ACLF with infection, summarizes the common types and clinical features of infection, reviews the recommended anti-infective regimens, and emphasizes the importance of early prophylactic treatment. ACLF patients with infection tend to have critical conditions, and early diagnosis and empirical anti-infective treatment is the key to successful treatment.
