Role of intestinal flora-mediated immune response in chronic hepatitis B virus infection
10.3969/j.issn.1001-5256.2019.11.039
- VernacularTitle:肠道菌群介导的免疫反应在慢性HBV感染中的作用
- Author:
Hui GAO
1
;
Shousheng LIU
;
Zhenzhen ZHAO
Author Information
1. Department of Infectious Diseases, Qingdao Municipal Hospital Affiliated to Qingdao University, Qingdao, Shandong 266011, China
- Publication Type:Research Article
- Keywords:
hepatitis B, chronic;
gastrointestinal microbiome;
immunomodulation;
fecal microbiota transplantation
- From:
Journal of Clinical Hepatology
2019;35(11):2565-2568
- CountryChina
- Language:Chinese
-
Abstract:
Hepatitis B virus (HBV) infection can cause acute or chronic liver injury. Chronic hepatitis B (CHB)-related liver cirrhosis and hepatocellular carcinoma usually lead to an increase in mortality, and their pathogenesis may be associated with immune response. Intestinal flora plays an important role in host metabolism and immune regulation, and the studies on “gut-liver axis” and intestinal flora have shown that the structural change of intestinal flora, bacterial translocation, and related immunologic injury may affect the development and progression of liver inflammation on the basis of CHB. This article summarizes and discusses the immunological role of intestinal flora in CHB and explores the potential treatment methods for HBV infection based on intestinal flora.
