Treatment of oral submucous fibrosis with local injection of salvia miltiorrhiza combined with triamcinolone acetonide: a meta-analysis
10.12016/j.issn.2096⁃1456.2018.06.007
- Author:
CAI Xinjia
1
;
HUANG Junhui
1
;
YAO Zhigang
1
;
LI Long
1
;
LIU Gui
1
;
LIU Junjie
1
;
LI Huiling
1
;
CUI Lin
1
Author Information
1. Department of Oral Pathology, Xiangya Stomatological Hospital, Central South University
- Publication Type:Journal Article
- Keywords:
Oral submucosal fibrosis;
Meta-analysis;
Salvia miltiorrhiza;
Triamcinolone acetonide
- From:
Journal of Prevention and Treatment for Stomatological Diseases
2018;26(6):374-378
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the efficacy of the local injection of Salvia miltiorrhiza combined with triamcinolone acetonide and triamcinolone acetonide alone in the treatment of oral submucous fibrosis (OSF).
Methods: A meta-analysis was performed by searching the related literature. Three randomized controlled trials meeting the inclusion criteria were identified. Changes in the Visual Analogue Scale (VAS) score and the degree of mouth opening were included in 172 cases (86 cases in the experimental group and 86 in the control group), and changes in the oral mucosal lesion area were included in 152 cases (76 cases in the experimental group and 76 in the control group). Changes in the VAS score, the degree of mouth opening and the oral mucosal lesion area were compared in the context of the local injection of Salvia miltiorrhiza combined with triamcinolone acetonide and triamcinolone acetonide alone.
Results : There were no significant differences between the treatment with Salvia miltiorrhiza combined with triamcinolone acetonide and triamcinolone acetonide alone in reducing the VAS score (P > 0.05). Salvia miltiorrhiza combined with triamcinolone acetonide resulted in a greater increase in the degree of mouth opening than did triamcinolone acetonide (P = 0.05). The reduction in the oral mucosal lesion area induced by Salvia miltiorrhiza combined with triamcinolone acetonide was significantly greater than that induced by triamcinolone acetonide alone (P < 0.05).
Conclusion:The local injection of Salvia miltiorrhiza combined with triamcinolone acetonide is more effective than triamcinolone acetonide alone in the treatment of OSF.
- Full text:丹参联合曲安奈德局部注射治疗口腔黏膜下纤维性变的meta分析.pdf
