Study progress of the correlation between peri-implantitis, IL-1β, TNF-α and NF-κB signal transduction
10.12016/j.issn.2096-1456.2018.10.012
- Author:
CHEN Yuxiong
1
;
HUANG Yuanjin
2
Author Information
1. Southern Medical University
2. Stomatological Hospital, Southern Medical University
- Publication Type:Review
- Keywords:
Peri-implantitis;
Interleukin-1β Tumor necrosis factor-α Receptor activator for nuclear factor-κB ligand;
Osteoprotegerin;
Nuclear transcription factor kappaB signaling pathways
- From:
Journal of Prevention and Treatment for Stomatological Diseases
2018;26(10):673-676
- CountryChina
- Language:Chinese
-
Abstract:
Increasing numbers of edentulous patients and patients with dental defects are willing to accept implant restorations. However, the development of peri-implantitis is a major factor leading to implant failure. The worsening of peri-implantitis promotes the secretion of inflammatory cytokines such as IL-1β and TNF-α and the gene expression of RANKL, inhibits the gene expression of OPG, and increases osteoclast activity, which promotes bone absorption indirectly and leads to a negative balance in bone metabolism. To gain knowledge about the relationship between peri-implantitis and NF-κB signaling pathways, this article summarizes related reports about peri-implantitis and NF-κB signaling pathways, explores the regulatory mechanism by which peri-implantitis affects bone metabolism and NF-κB signaling, discusses the effect of immunological cytokines on NF-κB signaling pathways when inflammation arises, and provides a theoretical foundation for peri-implantitis research and prevention.
- Full text:种植体周围炎中IL-1β、TNF-α、NF-κB信号通路研究进展.pdf
