The association between IGF1 gene rs1520220 polymorphism and cancer susceptibility: a meta-analysis based on 12,884 cases and 58,304 controls.
10.1186/s12199-018-0727-y
- Author:
Gui-Ping XU
1
;
Wei-Xian CHEN
2
;
Wen-Yue XIE
3
;
Li-Fang WU
4
Author Information
1. Transfusion Department, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
2. Department of Laboratory Medicine, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, China.
3. Department of Oncology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
4. Department of Laboratory Medicine, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, China. lifangwu0408@hotmail.com.
- Publication Type:Journal Article
- Keywords:
Cancer;
IGF1;
Meta-analysis;
Polymorphism;
rs1520220
- MeSH:
Asian Continental Ancestry Group;
Continental Population Groups;
Gene Frequency;
Genetic Predisposition to Disease;
Humans;
Insulin-Like Growth Factor I;
genetics;
Neoplasms;
ethnology;
genetics;
Odds Ratio;
Polymorphism, Single Nucleotide
- From:Environmental Health and Preventive Medicine
2018;23(1):38-38
- CountryJapan
- Language:English
-
Abstract:
BACKGROUND:The rs1520220 polymorphism in the insulin-like growth factor 1 (IGF1) gene has been reported to affect cancer susceptibly in several studies. However, the results of the relevant studies are inconsistent. We conduct a current meta-analysis to investigate the association between rs1520220 and cancer susceptibly.
METHODS:Three databases (PubMed, Embase, and Web of Science) were searched for studies regarding the relationship between rs1520220 and cancer susceptibly. Odds ratios (ORs) and the related 95% confidence intervals (CIs) were employed to assess the strength of the associations. A stratified analysis was performed according to cancer type, ethnicity, and quality score, and when results were obtained from no fewer than two studies, these results were pooled.
RESULTS:There was no positive association between rs1520220 and overall cancer risk. However, the analysis stratified by ethnicity revealed that rs1520220 significantly increased cancer susceptibility in Asian populations (allele model OR = 1.10, 95%Cl = 1.00-1.21, p = 0.040; homozygote model OR = 1.22, 95%Cl = 1.01-1.47, p = 0.040; dominant model OR = 1.19, 95%Cl = 1.01-1.39, p = 0.033). No significantly association was detected in Caucasian populations. The analysis stratified by cancer type suggested that rs1520220 was not associated with susceptibility to breast cancer.
CONCLUSIONS:The results of our meta-analysis demonstrate that the role of IGF1 rs1520220 in cancer susceptibility varies by ethnicity and cancer type and that rs1520220 increases cancer susceptibility in Asian populations.
