Age and gender-associated metabolic characteristics of urinary stone patients.
10.12729/jbr.2015.16.4.172
- Author:
Sang Keun LEE
1
;
Young Won KIM
;
Ho Won KANG
;
Won Tae KIM
;
Yong June KIM
;
Seok Joong YUN
;
Wun Jae KIM
;
Sang Cheol LEE
Author Information
1. Department of Urology, College of Medicine, Chungbuk National University, Cheongju 28644, Korea. lscuro@chungbuk.ac.kr
- Publication Type:Original Article
- Keywords:
urolithiasis;
aged,;
sex;
risk factors;
body mass index
- MeSH:
Aged;
Body Mass Index;
Calcium;
Chemistry;
Citric Acid;
Female;
Humans;
Hydrogen-Ion Concentration;
Incidence;
Male;
Retrospective Studies;
Risk Factors;
Uric Acid;
Urinary Calculi*;
Urolithiasis
- From:Journal of Biomedical Research
2015;16(4):172-176
- CountryRepublic of Korea
- Language:English
-
Abstract:
The aim of the present study was to investigate sex- and age-associated clinico-metabolic characteristics of urinary stone patients. A retrospective review was performed on data from 2,009 consecutive patients presenting with their first urinary stone episode between 2005 and 2013. Of the 2,009 patients, 1,426 (71.0%) satisfied the inclusion criteria and were enrolled in the study. Patients were grouped by age (<60, > or =60 years old) and sex. The medical history and 24 hr urinary chemistry results of each patient were obtained. The mean age of the 165 (11.6%) patients aged 60 or over was 65.5 +/- 4.2 years. Body mass index was greater in elderly females than in younger females (p=0.031). After stratification by sex and age, lower urinary excretion of calcium and uric acid was a protective factor for both sexes among the elderly (p<0.05, each, respectively). Low urine pH was a common risk factor for both sexes among the elderly (p=0.013 in males, p=0.047 in females, respectively), whereas lower citrate excretion was a risk factor for only the elderly female group (p=0.004). With regard to urinary metabolic abnormalities, elderly females showed higher incidence of hypocitraturia compared to younger females (p=0.049). In conclusion, this study demonstrated the sex- and ageassociated clinico-metabolic characteristics of urinary stone patients. Thus, it is important to tailor metabolic evaluation and medical prevention therapies for patient according to sex and gender characteristics.
