Dynamic cerebral autoregulation after confinement in an isolated environment for 14 days.
10.1186/s12199-018-0751-y
- Author:
Tomokazu KATO
1
;
Ryo YANAGIDA
1
;
Chiharu TAKKO
1
;
Takuya KURAZUMI
1
;
Natsuhiko INOUE
2
;
Go SUZUKI
2
;
Yojiro OGAWA
1
;
Satoshi FURUKAWA
2
;
Ken-Ichi IWASAKI
3
Author Information
1. Division of Hygiene, Department of Social Medicine, Nihon University School of Medicine, Oyaguchi-Kamicho, Itabashi-ku, Tokyo, 173-8610, Japan.
2. Japan Aerospace Exploration Agency, Ibaraki, 305-8505, Japan.
3. Division of Hygiene, Department of Social Medicine, Nihon University School of Medicine, Oyaguchi-Kamicho, Itabashi-ku, Tokyo, 173-8610, Japan. iwasaki.kenichi@nihon-u.ac.jp.
- Publication Type:Journal Article
- Keywords:
Cerebral circulation;
Isolated and confined environment;
Isolation;
Space medicine;
Transcranial Doppler;
Transfer function analysis
- MeSH:
Adult;
Cerebrovascular Circulation;
physiology;
Confined Spaces;
Homeostasis;
physiology;
Humans;
Male;
Middle Aged;
Space Flight;
Young Adult
- From:Environmental Health and Preventive Medicine
2018;23(1):61-61
- CountryJapan
- Language:English
-
Abstract:
BACKGROUND:To develop human space exploration, it is necessary to study the effects of an isolated and confined environment, as well as a microgravity environment, on cerebral circulation. However, no studies on cerebral circulation in an isolated and confined environment have been reported. Therefore, we investigated the effects of a 14-day period of confinement in an isolated environment on dynamic cerebral autoregulation.
METHODS:We participated in an isolation and confinement experiment conducted by the Japan Aerospace Exploration Agency in 2016. Eight healthy males were isolated and confined in a facility for 14 days. Data were collected on the days immediately before and after confinement. Arterial blood pressure waveforms were obtained using a finger blood pressure monitor, and cerebral blood flow velocity waveforms in the middle cerebral artery were obtained using transcranial Doppler ultrasonography for 6 min during quiet rest in a supine position. Dynamic cerebral autoregulation was evaluated by transfer function analysis between spontaneous variability of beat-to-beat mean arterial blood pressure and mean cerebral blood flow velocity.
RESULTS:Transfer function gain in the low- and high-frequency ranges increased significantly (0.54 ± 0.07 to 0.69 ± 0.09 cm/s/mmHg and 0.80 ± 0.05 to 0.92 ± 0.09 cm/s/mmHg, respectively) after the confinement.
CONCLUSION:The increases observed in transfer function gain may be interpreted as indicating less suppressive capability against transmission from arterial blood pressure oscillation to cerebral blood flow velocity fluctuation. These results suggest that confinement in an isolated environment for 14 days may impair dynamic cerebral autoregulation.
TRIAL REGISTRATION:UMIN000020703 , Registered 2016/01/22.
