Exposure profile of mercury, lead, cadmium, arsenic, antimony, copper, selenium and zinc in maternal blood, cord blood and placenta: the Tohoku Study of Child Development in Japan.
10.1186/s12199-019-0783-y
- Author:
Miyuki IWAI-SHIMADA
1
;
Satomi KAMEO
2
;
Kunihiko NAKAI
3
;
Kozue YAGINUMA-SAKURAI
4
;
Nozomi TATSUTA
3
;
Naoyuki KUROKAWA
5
;
Shoji F NAKAYAMA
6
;
Hiroshi SATOH
7
Author Information
1. Centre for Health and Environmental Risk Research, National Institute for Environmental Studies, Tsukuba, Ibaraki, Japan. iwai.miyuki@nies.go.jp.
2. Department of Nutrition, College of Nutrition, Koshien University, Takarazuka, Hyogo, Japan.
3. Department of Development and Environmental Medicine, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan.
4. Department of Human Health and Nutrition, Faculty of Comprehensive Human Sciences, Shokei Gakuin University, Sendai, Miyagi, Japan.
5. Miyagi University of Education, Sendai, Miyagi, Japan.
6. Centre for Health and Environmental Risk Research, National Institute for Environmental Studies, Tsukuba, Ibaraki, Japan.
7. Tohoku University, Sendai, Miyagi, Japan.
- Publication Type:Journal Article
- Keywords:
Cord blood;
Maternal blood;
Metal;
Placenta;
Trace element
- MeSH:
Adult;
Female;
Fetal Blood;
chemistry;
Humans;
Japan;
Maternal Exposure;
statistics & numerical data;
Maternal-Fetal Exchange;
Metals;
blood;
Placenta;
chemistry;
Pregnancy;
blood;
Trace Elements;
blood;
Urban Health
- From:Environmental Health and Preventive Medicine
2019;24(1):35-35
- CountryJapan
- Language:English
-
Abstract:
BACKGROUND:The effects of prenatal exposure to toxic elements on birth outcomes and child development have been an area of concern. This study aimed to assess the profile of prenatal exposure to toxic elements, arsenic (As), bismuth (Bi), cadmium (Cd), mercury (total mercury (THg), methylmercury (MHg), inorganic mercury (IHg)), lead (Pb), antimony (Sb) and tin (Sn), and essential trace elements, copper (Cu), selenium (Se) and zinc (Zn), using the maternal blood, cord blood and placenta in the Tohoku Study of Child Development of Japan (N = 594-650).
METHODS:Inductively coupled plasma mass spectrometry was used to determine the concentrations of these elements (except mercury). Levels of THg and MeHg were measured using cold vapour atomic absorption spectrophotometry and a gas chromatograph-electron capture detector, respectively.
RESULTS:Median concentrations (25th-75th) of As, Cd, Pb, Sb, Sn and THg in the maternal blood were 4.06 (2.68-6.81), 1.18 (0.74-1.79), 10.8 (8.65-13.5), 0.2 (0.06-0.40) and 0.2 (0.1-0.38) ng mL and 5.42 (3.89-7.59) ng g, respectively. Median concentrations (25th-75th) of As, Cd, Pb, Sb, Sn and THg in the cord blood were 3.68 (2.58-5.25), 0.53 (0.10-1.25), 9.89 (8.02-12.5), 0.39 (0.06-0.92) and 0.2 (0.2-0.38) ng mL and 9.96 (7.05-13.8) ng g, respectively.
CONCLUSIONS:THg and Sb levels in the cord blood were twofold higher than those in the maternal blood. Cord blood to maternal blood ratios for As, Cd and Sb widely varied between individuals. To understand the effects of prenatal exposure, further research regarding the variations of placental transfer of elements is necessary.
