Associations between metal concentrations in whole blood and placenta previa and placenta accreta: the Japan Environment and Children's Study (JECS).
10.1186/s12199-019-0795-7
- Author:
Mayumi TSUJI
1
;
Eiji SHIBATA
2
;
David J ASKEW
2
;
Seiichi MOROKUMA
3
;
Yukiyo AIKO
2
;
Ayako SENJU
4
;
Shunsuke ARAKI
5
;
Masafumi SANEFUJI
3
;
Yasuhiro ISHIHARA
6
;
Rie TANAKA
7
;
Koichi KUSUHARA
4
;
Toshihiro KAWAMOTO
7
;
Japan Environment and Children’s Study Group
Author Information
1. Department of Environmental Health, University of Occupational and Environmental Health, Kitakyushu, Japan. tsuji@med.uoeh-u.ac.jp.
2. Department of Obstetrics and Gynecology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
3. Research Center for Environmental and Developmental Medical Sciences, Kyushu University, Fukuoka, Japan.
4. Japan Environment and Children's Study, University of Occupational and Environmental Health Subunit Center, University of Occupational and Environmental Health, Kitakyushu, Fukuoka, Japan.
5. Department of Pediatrics, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
6. Laboratory of Molecular Brain Science, Graduate School of Integrated Arts and Sciences, Hiroshima University, Higashi-Hiroshima, Japan.
7. Department of Environmental Health, University of Occupational and Environmental Health, Kitakyushu, Japan.
- Collective Name:Japan Environment and Children’s Study Group
- Publication Type:Journal Article
- Keywords:
Metal concentration;
Placenta accreta;
Placenta previa;
Pregnancy
- MeSH:
Adult;
Cross-Sectional Studies;
Female;
Humans;
Japan;
Metals, Heavy;
blood;
metabolism;
Placenta Accreta;
metabolism;
Placenta Previa;
metabolism;
Pregnancy;
Selenium;
blood;
metabolism
- From:Environmental Health and Preventive Medicine
2019;24(1):40-40
- CountryJapan
- Language:English
-
Abstract:
BACKGROUND:Placenta previa and placenta accreta associate with high morbidity and mortality for both mothers and fetus. Metal exposure may have relationships with placenta previa and placenta accreta. This study analyzed the associations between maternal metal (cadmium [Cd], lead [Pb], mercury [Hg], selenium [Se], and manganese [Mn]) concentrations and placenta previa and placenta accreta.
METHODS:We recruited 17,414 women with singleton pregnancies. Data from a self-administered questionnaire regarding the first trimester and medical records after delivery were analyzed. Maternal blood samples were collected to measure metal concentrations. The subjects were classified into four quartiles (Q1, Q2, Q3, and Q4) according to metal concentrations.
RESULTS:The odds ratio for placenta previa was significantly higher among subjects with Q4 Cd than those with Q1 Cd. The odds ratio for placenta previa was significantly higher for subjects with Q2 Pb than those with Q1 Pb.
CONCLUSION:Participants with placenta previa had higher Cd concentrations. However, this study was cross-sectional and lacked important information related to Cd concentration, such as detailed smoking habits and sources of Cd intake. In addition, the subjects in this study comprised ordinary pregnant Japanese women, and it was impossible to observe the relationship between a wide range of Cd exposure and placenta previa. Therefore, epidemiological and experimental studies are warranted to verify the relationship between Cd exposure and pregnancy abnormalities.
