Quality evaluation of Magnoliae Officinalis Cortex based on combinative method of fingerprint,quantitative analysis of multicomponents and chemometrics.
10.19540/j.cnki.cjcmm.20181226.018
- Author:
Wen-Guang JING
1
;
Quan ZHANG
2
;
Zhe DENG
2
;
Ji-Yong WANG
2
;
Xiao-Bo SUN
3
;
Qing-Shan LAN
2
Author Information
1. Institute of Medicinal Plant Development,Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100193,China Department of Research and Development,China National Traditional Chinese Medicine Co.,Ltd. Beijing 102600,China.
2. Department of Research and Development,China National Traditional Chinese Medicine Co.,Ltd. Beijing 102600,China.
3. Institute of Medicinal Plant Development,Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100193,China.
- Publication Type:Journal Article
- Keywords:
Magnoliae Officinalis Cortex;
chemometrics methods;
fingerprint analysis;
quality evaluation;
simultaneous determination
- MeSH:
Chromatography, High Pressure Liquid;
Discriminant Analysis;
Drugs, Chinese Herbal;
standards;
Magnolia;
chemistry;
Phytochemicals;
analysis;
standards;
Quality Control
- From:
China Journal of Chinese Materia Medica
2019;44(5):975-982
- CountryChina
- Language:Chinese
-
Abstract:
This study aims to establish a combinative method based on fingerprint,assay of multi-component and chemometrics for quality evaluation of Magnoliae Officinalis Cortex. Twenty batches of samples were determined by UPLC and a common mode of fingerprint was established. The similarities between fingerprints of 20 batches of samples were over 0. 90 and the common mode were evaluated. Eight components were identified as syringing, magnocurarine, magnoflorine, magnoloside B, magnoloside A, honokiol,magnolol,and piperitylmagnolol by comparison with reference substances and their content in samples were simultaneously determined.Based on the results,the fingerprint had good consistency between the same origin and minor diversity between the different sources.Piperitylmagnolol and peak 13 could be used as a distinction with the different sources. According to content of 8 components,Fisher discriminant analysis model was established and different source sample was classified pursuant to the discriminant fraction. It is indicated that simultaneous quantification of multi components coupled with chemometrics analysis could be a well-acceptable strategy to identify and evaluate the quality of Magnoliae Officinalis Cortex.
