Effect of fresh Gastrodia elata on gut microbiota in mice.
10.19540/j.cnki.cjcmm.2019.0018
- Author:
Zhong-Yi HUA
1
;
Hong-Mei LI
2
;
Jian-Hui SUN
2
;
Hai-Ru HUO
2
;
Xiao-Qin LI
2
;
Lu-Qi HUANG
1
;
Yuan YUAN
1
Author Information
1. National Resource Center for Chinese Materia Medical,China Academy of Chinese Medical Sciences Beijing 100700,China.
2. Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences Beijing 100700,China.
- Publication Type:Journal Article
- Keywords:
Gastrodia elata;
gut microbiome;
medicine-food plants;
metabolic diseases;
probiotics
- MeSH:
Animals;
Drugs, Chinese Herbal;
pharmacology;
Gastrodia;
chemistry;
Gastrointestinal Microbiome;
drug effects;
Medicine, Chinese Traditional;
Mice;
Plant Extracts;
pharmacology;
Plants, Medicinal;
chemistry;
RNA, Ribosomal, 16S;
genetics
- From:
China Journal of Chinese Materia Medica
2019;44(5):1004-1009
- CountryChina
- Language:Chinese
-
Abstract:
Gastrodia elata B1.,a traditional Chinese medicine,was frequently applied as a cure for headache or migraine. Its effects include suppressing hyperactive liver,calming endogenous wind,dredging collateralsand relieving spasm. There has been a proportion that G. elata should be added to The List of Substances That Are Traditionally Both Food and Chinese Medicinal Materials. The dry G. elata was commonly used in clinic,which have some fundamental study on efficacy and mechanism. However,fresh G. elata,which was added to herbal cuisine very often,lacks corresponding research. The interaction of diet,microbiota and human is a hot issue and lots of scholars are focusing on it. This research sequenced the 16 S rRNA of mouse cecal contents on Mi Seq platform to understand the effect of taking fresh G. elata. As the results showing,multiple probiotics grew after taking fresh G. elata extract,including Ruminiclostridium,Butyricicoccus,and Parvibacter. To contrast,some pathogens or potential pathogens,such as Escherichia/Shigella,Parasutterella,decreased. This manifests that fresh G. elata performs a positive regulation on mouse gut microbiota,especially the low-dose fresh G. elata extraction could restructure the microbiota apparently. Our result reveals that microbiota might be a new target for G. elata extract and provides an important basis for further research on the interaction between gut microbiota and pharmacological activity of G. elata.
