Effective components of traditional Chinese medicine for regulating TGF-Beta1/Smads signaling pathway in hepatic fibrosis.
10.19540/j.cnki.cjcmm.20181221.006
- Author:
Le WANG
1
;
Teng DING
2
;
Wei-Ling GONG
1
;
Chang-Hua YANG
3
;
Feng LIU
4
Author Information
1. Shaanxi University of Chinese Medicine Xianyang 712046,China Shaanxi Institute of International Trade & Commerce Xianyang 712046,China.
2. Shaanxi University of Chinese Medicine Xianyang 712046,China.
3. Shaanxi Institute of International Trade & Commerce Xianyang 712046,China Shaanxi Provincial Collaborative Innovation Center of Green Manufacturing Technology for Traditional Chinese Medicine Xi'an 710075,China.
4. Shaanxi Institute of International Trade & Commerce Xianyang 712046,China Shaanxi Buchang Pharmaceutical Limited Company Xi'an 710075,China Shaanxi Provincial Collaborative Innovation Center of Green Manufacturing Technology for Traditional Chinese Medicine Xi'an 710075,China.
- Publication Type:Journal Article
- Keywords:
TGF-β1/Smads signaling pathway;
effective components of traditional Chinese medicine;
hepatic fibrosis
- MeSH:
Animals;
Drugs, Chinese Herbal;
Liver Cirrhosis;
Medicine, Chinese Traditional;
Signal Transduction;
Smad Proteins;
Transforming Growth Factor beta1
- From:
China Journal of Chinese Materia Medica
2019;44(4):666-674
- CountryChina
- Language:Chinese
-
Abstract:
Hepatic fibrosis is a liver damage healing response affected by a variety of factors; its formation is associated with multiple cytokines and a variety of signaling pathways. Transforming growth factor beta1( TGF-β1) is one of the strongest fibrosis cytokines known,and involves almost all the key links in hepatic fibrosis. TGF-β1/Smads signal pathway is the most classical pathway for TGF-β1 to play its role in promoting fibrosis as well as one of the most important signaling pathways of hepatic fibrosis formation. Studies for the signal pathway have made a series of scientific research achievements in recently years. Traditional Chinese medicine has the advantages of " multiple ingredients,multiple targets and less side effects",and is widely used in the clinical treatment of hepatic fibrosis.Effective components of traditional Chinese medicine are monomer compounds,which are extracted and purified from traditional Chinese medicine. Nowadays,the molecular biology studies of effective traditional Chinese medicine have become a hotspot. Modern advanced technology and methods can be used to directly clarify the targets and the signaling pathways,reveal the mechanism of traditional Chinese medicine in treating diseases,and promote the modernization and international development of traditional Chinese medicine industry. This review summarized the structure,function and application of TGF-β1/Smads signaling pathway in the progress of anti-hepatic fibrosis,and analyzed the action mode and possible mechanism of various effective components of traditional Chinese medicine in regulating TGF-β1/Smads signaling pathway and intervening the treatment of hepatic fibrosis in the past five years,so as to put forward new ideas for innovating new targeted traditional Chinese medicine for hepatic fibrosis.
