Chemical constituents from rhizome of Menispermum dauricum and their anti-hypoxic activities.
10.19540/j.cnki.cjcmm.20181121.003
- Author:
Jia SHAO
1
;
Chao-Feng SHI
2
;
Jin-Xia WEI
2
;
Ya-Xiao LI
2
;
Xing-Jie GUO
3
Author Information
1. Department of Pharmacy,Tianjin First Central Hospital Tianjin 300192,China Department of Health Service,Logistics College of Chinese People's Armed Police Forces Tianjin 300309,China.
2. Department of Health Service,Logistics College of Chinese People's Armed Police Forces Tianjin 300309,China.
3. School of Pharmacy,Shenyang Pharmaceutical University Shenyang 110016,China.
- Publication Type:Journal Article
- Keywords:
Menispermum dauricum;
alkaloids;
anti-hypoxia activities;
chemical constituents
- MeSH:
Alkaloids;
Humans;
Hypoxia;
Menispermum;
Plant Extracts;
Rhizome
- From:
China Journal of Chinese Materia Medica
2019;44(4):723-729
- CountryChina
- Language:Chinese
-
Abstract:
To study the chemical constituents from the rhizome of Menispermum dauricum,fifteen compounds,N-methylcorydaldine( 1),thalifoline( 2),stepholidine( 3),acutumine( 4),daurisoline( 5),acutumidine( 6),dauricicoline( 7),bianfugecine( 8),6-O-demethylmenisporphine( 9),bianfugedine( 10),dauricoside( 11),eleutheroside D( 12),aristolactone( 13),aristoloterpenateⅠ( 14) and aristolochic acid( 15) were isolated from 75% ethanol extract of Menispermi Rhizoma by using thin layer chromatography and column chromatography methods. Their structures were identified based on their physicochemical properties and spectral data. Among them,compounds 12-15 were obtained from the genus Menispermum for the first time. Six alkaloids with higher contents were subjected to evaluate the anti-hypoxic activities by using MTT method. As a result,six alkaloids exhibited significant anti-hypoxia activities.
