Application of active components from traditional Chinese medicine in treatment of inflammatory bowel disease.
10.19540/j.cnki.cjcmm.20180907.001
- Author:
Mei-Juan SHAO
1
;
Yu-Xi YAN
2
;
Qing QI
2
;
Wei TANG
2
;
Jian-Ping ZUO
1
Author Information
1. Research Center for Science and Technology, Shanghai University of Traditional Chinese Medicine Shanghai 201203, China Shanghai Institute of Materia Medica, Chinese Academy of Sciences Shanghai 201203, China.
2. Shanghai Institute of Materia Medica, Chinese Academy of Sciences Shanghai 201203, China.
- Publication Type:Journal Article
- Keywords:
T cells;
active ingredients of traditional Chinese medicine;
barrier injury;
inflammatory bowel disease;
inflammatory factors
- MeSH:
Humans;
Inflammatory Bowel Diseases;
therapy;
Intestinal Mucosa;
drug effects;
physiopathology;
Medicine, Chinese Traditional
- From:
China Journal of Chinese Materia Medica
2019;44(3):415-421
- CountryChina
- Language:Chinese
-
Abstract:
Inflammatory bowel disease(IBD) is a non-specific and chronic recurrent autoimmune disease that involves the gastrointestinal tract. Clinical symptoms of intestinal bleeding, diarrhea, and weight loss threat to human health and induce colorectal cancer. The pathogenesis included living environment, genetic factors, immune cell infiltration and immune stress, weakened mucosal barrier defense and intestinal flora imbalance. At present, clinical treatment drugs mainly include aminosalicylic acid, corticosteroids, immunosuppressants, biological agents, etc., in view of the disadvantages of poor therapeutic effect and expensive price. The active ingredients of traditional Chinese medicine(TCM) in the treatment IBD have various biological activities and multiple targets such as anti-inflammatory, antibacterial, anti-tumor and immune regulation. This article summarized the application and the research progress in protecting intestinal epithelial barrier, maintaining intestinal microbial homeostasis, inhibiting causative factors, and regulating Th1/Th17/Treg balance about TCM in the treatment of IBD. The review provided new ideas for further development of the new drugs on the mechanism based on active ingredients of TCM in IBD treatment.
