Study on chemical constituents from fruiting bodies of Ganoderma australe.
10.19540/j.cnki.cjcmm.20181121.004
- Author:
Ya-Zhe GE
1
;
Qing-Yun MA
2
;
Fan-Dong KONG
2
;
Qing-Yi XIE
2
;
Chang-Liang AN
3
;
Zhi-Fang YU
3
;
You-Xing ZHAO
2
Author Information
1. College of Food Science and Technology, Nanjing Agricultural University Nanjing 210095, China Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences Haikou 571101, China.
2. Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences Haikou 571101, China.
3. College of Food Science and Technology, Nanjing Agricultural University Nanjing 210095, China.
- Publication Type:Journal Article
- Keywords:
Ganoderma australe;
anti-oxidative ability;
chemical constituents;
α-glucoitsidase inhibitory activity
- MeSH:
Free Radical Scavengers;
isolation & purification;
Fruiting Bodies, Fungal;
chemistry;
Ganoderma;
chemistry;
Glycoside Hydrolase Inhibitors;
isolation & purification;
Molecular Structure
- From:
China Journal of Chinese Materia Medica
2019;44(3):489-494
- CountryChina
- Language:Chinese
-
Abstract:
Chemical constituents were isolated from the fruiting bodies of Ganoderma australe by various column chromatographic techniques and HPLC method, and their chemical structures were identified through the combined analysis of physicochemical properties and spectral data. Meanwhile, their α-glucosidase inhibitory activity and anti-oxidative ability were evaluated. Seven compounds were isolated from G. australe and were identified as 6-methoxyl-cyclo-(Phe-Ile)(1), applanoxidic acid A methyl ester(2), ergosta-7,22 E-dien-3β-ol(3), cinnamic acid(4), 5α,8α-epidioxy-(20S,22E,24R)-ergosta-6,22-diene-3β-ol(5), 1-(3, 4-dihydroxyphenyl) ethanone(6), salicylic acid(7) and benzoic acid(8). Among the compounds, compound 1 was a new cyclic dipeptide. Compound 2 was a new lanosta natural product, and compounds 4, 6, 7 and 8 were obtained from G. australe for the first time. Moreover, compounds 4 and 8 exhibited α-glucosidase inhibitory activity with inhibition rates of 36.8% and 34.7%, and compounds 4, 7 and 8 had a certain activity in DPPH free radical scavenging activity with IC_(50) values of 0.168, 0.458 and 0.170 g·L~(-1), respectively. The DPPH radical scavenging rate of compound 1 was 41.1%.
