Incompatibility mechanism of Crotonis Semen Pulveratum and Glycyrrhizae Radix et Rhizoma based on diuretic effect and intestinal flora structure.
10.19540/j.cnki.cjcmm.20181012.002
- Author:
Yao LI
1
;
Sheng GUO
1
;
Wei-Wei TAO
1
;
Jin-Gao YU
1
;
Shu-Lan SU
1
;
Jin-Ao DUAN
1
Author Information
1. Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, and Jiangsu Key Laboratory for High Technology Research of Traditional Chinese Medicine Formulae, Nanjing University of Chinese Medicine Nanjing 210023, China.
- Publication Type:Journal Article
- Keywords:
Crotonis Semen Pulveratum;
Glycyrrhizae Radix et Rhizoma;
diuretic effect;
incompatibility;
intestinal flora
- MeSH:
Animals;
Croton;
chemistry;
Diuretics;
Drug Interactions;
Drugs, Chinese Herbal;
pharmacology;
Gastrointestinal Microbiome;
drug effects;
Glycyrrhiza;
chemistry;
Intestines;
Mice;
Plant Roots;
chemistry;
Seeds;
chemistry
- From:
China Journal of Chinese Materia Medica
2019;44(3):518-525
- CountryChina
- Language:Chinese
-
Abstract:
Based on the toxic characteristics caused by the compatibility between "Zaoji Suiyuan" and Glycyrrhizae Radix et Rhizoma, which was found in the previous studies, the expanded study was carried out on the incompatibility mechanism between Crotonis Semen Pulveratum(CT) and Glycyrrhizae Radix et Rhizoma(GU) with the diuretic effect and intestinal flora as the characteristic indexes. The results showed that GU could slow down the rapid diuretic effect of CT, which suggested a tendency of decreasing the efficacy. Both the high and low dose of CT could significantly induce the intestinal injury and change the intestinal bacteria structure of mice. Low dose CT combined with GU could significantly increase the levels of Streptococcus and Rikenellaceae＿ukn. The relative abundance of Desulfovibrio and Streptococcaceae＿ukn were increased after the combined application of high dose CT and GU. It also suggested that there was a risk of inflammation in the liver and intestines when combined application of these two herbs. The results revealed that the combination of CT and GU has a tendency to reduce the clinical effect and increase the toxicity from the aspects of its traditional efficacy and its effect on intestinal microflora structure, which could provide the data for the clinical use of CT.
