Nature-effect relationship research of Salviae Miltiorrhizae Radix et Rhizoma and Carthami Flos based on nature combination.
10.19540/j.cnki.cjcmm.20180903.002
- Author:
Ning HOU
1
;
Dong-Xue WU
1
;
Min LIU
1
;
Jing LI
1
;
Yan-Ling ZHANG
1
;
Yan-Jiang QIAO
1
Author Information
1. State Administration of Traditional Chinese Medicine,Research Center of Traditional Chinese Medicine-Information Engineering,Beijing University of Chinese Medicine Beijing 100102,China.
- Publication Type:Journal Article
- Keywords:
Carthami Flos;
Salviae Miltiorrhizae Radix et Rhizoma;
cold-bitter;
nature combination;
promoting blood circulation and removing blood stasis;
warm-pungent
- MeSH:
Blood Coagulation;
Carthamus;
chemistry;
Databases, Pharmaceutical;
Drugs, Chinese Herbal;
pharmacology;
Flowers;
chemistry;
Humans;
Lipid Metabolism;
Medicine, Chinese Traditional;
Plant Roots;
chemistry;
Rhizome;
chemistry;
Salvia miltiorrhiza;
chemistry
- From:
China Journal of Chinese Materia Medica
2019;44(2):224-228
- CountryChina
- Language:Chinese
-
Abstract:
Salviae Miltiorrhizae Radix et Rhizoma and Carthami Flos are commonly traditional Chinese medicines with invigorating blood circulation and eliminating blood stasis,but they are different in effects due to differences in five tastes and four properties. In this study,Salviae Miltiorrhizae Radix et Rhizoma and Carthami Flos are selected as research vectors to obtain the active ingredients and targets through TCMD,TCMSP database and Ch EMBL database. The protein interaction information of the target is used to obtain from STRING online database,then imported into Cytoscape software to plot the protein interaction network and perform GO enrichment analysis.The results show that the heart-liver protein interaction network,involving blood circulation and hepatic lipid metabolism,thereby exerting the effect of activating blood circulation. The cold-bitter protein interaction network involves the biological process of vasoconstriction,thereby exerting cooling blood and the efficacy of eliminating phlegm. The warm-pungent protein interaction network involves blood coagulation,lipid metabolism and other biological processes to play the role of phlegm pain. Through analysis,it is found that the relationship between pharmacological efficacy and medicinal properties has a certain degree of specificity,which facilitates the subsequent scientific and systematic study of medicinal properties on the basis of this study.
