Basic research of fibrosis on atherosclerotic plaque stability and related drug application.
10.19540/j.cnki.cjcmm.20181012.005
- Author:
Jie YIN
1
;
Qi LI
2
;
Zheng ZHAO
2
;
Qing YANG
2
;
Yu-Jie LI
2
;
Ying CHEN
2
;
Ya-Jie WANG
2
;
Xiao-Gang WENG
2
;
Wei-Yan CAI
2
;
Xiao-Xin ZHU
2
Author Information
1. School of Chinese Materia Medica,Capital Medical University Beijing 100069,China.
2. Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences Beijing 100700,China.
- Publication Type:Journal Article
- Keywords:
atherosclerosis;
drug application;
fibrosis;
inflammation regulation;
plaque stability
- MeSH:
Atherosclerosis;
drug therapy;
pathology;
Cytokines;
Fibrosis;
Humans;
Inflammation;
Plaque, Atherosclerotic;
drug therapy;
pathology;
Thrombosis;
drug therapy;
pathology
- From:
China Journal of Chinese Materia Medica
2019;44(2):235-241
- CountryChina
- Language:Chinese
-
Abstract:
In the background of the high incidence and high mortality of cardiovascular diseases,atherosclerosis is the main pathological feature of cardiovascular diseases and the core pathological basis for disease progression. In the evolution of atherosclerotic plaques,the rupture of unstable plaques,plaque shedding and formation of thrombosis are the most dangerous parts. In this process,the formation of plaque fibrosis is the core mechanism regulating plaque stability. Additionally,fibrosis reflects dynamic changes in the inflammatory processes and pathological changes. In view of the inflammation regulation and fibrosis regulation,this paper clarified the process of atherosclerotic plaque,explained the roles of relevant inflammatory cells and cytokines in plaque stability,and summed up drug researches related with stable plaque in recent years. In the future,improving the fibrosis will be a new idea for stabilizing plaque in atherosclerosis drug development.
