Klebsiella Pneumoniae Visceral Organ Abscesses - Clinical Characteristics.
- Author:
Shuwei ZHENG
1
;
Seow Yen TAN
;
Helen Ml OH
Author Information
1. Division of Infectious Diseases, Changi General Hospital, Singapore.
- Publication Type:Journal Article
- MeSH:
Abscess;
classification;
microbiology;
mortality;
therapy;
Anti-Bacterial Agents;
therapeutic use;
Diabetes Mellitus;
epidemiology;
Female;
Humans;
Klebsiella pneumoniae;
isolation & purification;
Liver;
pathology;
Male;
Middle Aged;
Retrospective Studies;
Risk Factors;
Singapore;
epidemiology;
Survival Analysis;
Urogenital System;
pathology;
Viscera;
pathology
- From:Annals of the Academy of Medicine, Singapore
2019;48(2):48-54
- CountrySingapore
- Language:English
-
Abstract:
INTRODUCTION:In recent years, () has emerged as the predominant cause of pyogenic liver abscess in Asia. - as the causative microorganism in other visceral organ abscesses-is less described. In this study, we seeked to describe the clinical characteristics of visceral organ abscesses in our institution and evaluated the prescription practices of physicians with regard to antibiotic therapy.
MATERIALS AND METHODS:A retrospective analysis of patients with culture positive (blood or abscess aspirate) visceral organ abscesses from May 2014 to April 2016 requiring hospitalisation in Changi General Hospital was conducted.
RESULTS:A total of 140 adult patients with visceral organ abscesses were identified. The commonest site of involvement was the liver (77.9%), followed by genitourinary tract (20.7%). Diabetic patients were more likely to have liver abscesses, genitourinary abscesses, abscesses in 2 or more organs, genitourinary disease with abscess formation outside of the genitourinary tract, and endovascular infection. Patients with extended spectrum beta-lactamase producing , were more likely to have an obstructive lesion related to the site of the abscess. Overall mortality rate was 7.1%. Amongst survivors, the mean total duration of parenteral antimicrobial therapy was 2.5 weeks before switching to oral antimicrobial agents.
CONCLUSION:Genitourinary tract is the commonest extra-hepatic site for visceral organ abscess in infections. Parenteral to oral switch of antimicrobial agents appears to be a safe and effective treatment option.
