A Case of Carbamazepine Induced pseudolymphoma Syndrome.
- Author:
Hyun Cheol KIM
;
Yun Kyew KIM
;
Young Soo CHAE
;
Kee Suck SUH
;
Sang Tae KIM
- Publication Type:Case Report
- Keywords:
Carbamazepine;
Pseudolymphoma Syndrome
- MeSH:
Anticonvulsants;
Arthralgia;
Carbamazepine*;
Dermis;
Edema;
Eosinophilia;
Exanthema;
Fever;
Humans;
Hypersensitivity;
Leukocytosis;
Liver Function Tests;
Lymphatic Diseases;
Lymphoma;
Middle Aged;
Prednisolone;
Pseudolymphoma*;
Skin
- From:Korean Journal of Dermatology
1995;33(4):775-779
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The pseudolymphoma syndrome that may mimic malignant lymphoma clinically and histopathologically has been described as a hypersensitivity reaction to anticonvulsant drugs. It consists of the triad of a fever, generalized rash and lyrnphadenopathy. In some cases, varying degrees of malaise, hepatosplenornegaly, abnormal liver function tests, arthralgias, eosinophilia and blood dyscriasias may also be present. We report a case of pseudolymphoma syndrome due to carbamazepine in a 47-year-old man. He had a diffuse edematous and erythematous patches, papules and vesicles associated with high fever, hepatosplenomegaly and lymphadenopathy. The histopathologic finding slowed a dense atypical mononuclear cell infiltrate of the upper dermis associated with Pautriers microabscess like structures and severe dermal edema. Laboratory findings revealed leukocytosis and an abnormal liver function test. Three weeks after the withdrawal of carbamazepine and treatment with oral prednisolone, his skin lesion and general condition markedly improved.
