New advances in renal mechanisms of high fructose-induced salt-sensitive hypertension.
- Author:
Chuan-Ming XU
1
;
Tian-Xin YANG
1
Author Information
1. Institute of Hypertension, Sun Yat-sen University School of Medicine, Guangzhou 510080, China.
- Publication Type:Journal Article
- MeSH:
Blood Pressure;
Fructose;
adverse effects;
Humans;
Hypertension;
chemically induced;
physiopathology;
Kidney;
physiopathology;
Nitric Oxide;
metabolism;
Reactive Oxygen Species;
metabolism;
Renin-Angiotensin System;
Sodium Chloride, Dietary;
adverse effects;
Sodium-Hydrogen Exchanger 3;
metabolism;
Uric Acid;
metabolism
- From:
Acta Physiologica Sinica
2018;70(6):581-590
- CountryChina
- Language:English
-
Abstract:
Fructose intake has increased dramatically over the past century and the upward trend has continued until recently. Increasing evidence suggests that the excessive intake of fructose induces salt-sensitive hypertension. While the underlying mechanism is complex, the kidney likely plays a major role. This review will highlight recent advances in the renal mechanisms of fructose-induced salt-sensitive hypertension, including (pro)renin receptor-dependent activation of intrarenal renin-angiotensin system, increased nephron Na transport activity via sodium/hydrogen exchanger 3 and Na/K/2Cl cotransporter, increased renal uric acid production, decreased renal nitric oxide production, and increased renal reactive oxygen species production, and suggest actions based on these mechanisms that have therapeutic implications.
