Urinary biomarkers for chronic kidney disease: a focus on gene transcript.
- Author:
Lin-Li LYU
1
;
Bi-Cheng LIU
2
Author Information
1. Institute of Nephrology, Zhongda Hospital, Southeast University, Nanjing 210009, China.
2. Institute of Nephrology, Zhongda Hospital, Southeast University, Nanjing 210009, China. liubc64@163.com.
- Publication Type:Journal Article
- MeSH:
Biomarkers;
urine;
Humans;
MicroRNAs;
urine;
RNA, Messenger;
urine;
Renal Insufficiency, Chronic;
diagnosis;
urine
- From:
Acta Physiologica Sinica
2018;70(6):644-648
- CountryChina
- Language:Chinese
-
Abstract:
Chronic kidney disease (CKD) is becoming an alarming health burden worldwide, however, there is still lack of early biomarkers and effective treatment options. Thus, in the upcoming era of precision medicine, searching for the sensitive, non-invasive biomarkers has been the cornerstone and major challenge in the management of CKD. Urine contains rich biological information which could be an ideal source for non-invasive biomarkers of CKD. This review will discuss the recent advances in biomarker study from urine sediment, urine supernatant and urinary extracellular vesicles with special interest in gene transcript (miRNA, mRNA) biomarkers. Besides, the challenges and future directions for urinary gene transcript biomarker study will be discussed.
