Molecular mechanism of vascular remodeling in hypertension and Chinese medicine intervention.
- Author:
Chan-Juan ZHANG
1
;
Ya-Ning SHI
1
;
Duan-Fang LIAO
2
;
Ke DU
1
;
Li QIN
1
Author Information
1. Department of Pharmacology, School of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China.
2. Division of Stem Cell Regulation and Application, Hunan University of Chinese Medicine, Changsha 410208, China.
- Publication Type:Journal Article
- MeSH:
Humans;
Hypertension;
physiopathology;
therapy;
Medicine, Chinese Traditional;
Signal Transduction;
Vascular Remodeling
- From:
Acta Physiologica Sinica
2019;71(2):235-247
- CountryChina
- Language:Chinese
-
Abstract:
Vascular remodeling is a significant pathological characteristic of hypertension, which is regulated by complex regulatory networks. The vascular remodeling may be adaptive initially, however it becomes maladaptive and decompensation eventually and further compromises target organ function, leading to hypertensive cardiovascular complications. This review focuses on the role and mechanisms of vascular remodeling in the pathogenesis and progression of hypertension and its complications. Moreover, the strategies of syndrome differentiation of traditional Chinese medicine application provide clinical and theoretical evidences for hypertensive vascular remodeling therapy. A better understanding of underlying signaling pathways, therapeutic targets in vascular remodeling, as well as screening of active ingredients from traditional Chinese medicine may be able to provide some effective approaches for vascular protection in hypertensive diseases.
