Modulation of drug-metabolizing enzymes and transporters under hypoxia environment.
- Author:
Qiong MIN
1
;
Shi-Lan FENG
2
;
Hui LU
3
;
Wen-Bin LI
3
;
Chang WANG
3
;
Juan-Hong ZHANG
3
;
Rong WANG
1
Author Information
1. College of Pharmacy, Lanzhou University, Lanzhou 730000, China.
2. College of Pharmacy, Lanzhou University, Lanzhou 730000, China. fengshl@lzu.edu.cn.
3. Key Laboratory of the Plateau Environmental Damage Control, Lanzhou General Hospital of Lanzhou Military Command, PLA, Lanzhou 730050, China.
- Publication Type:Journal Article
- MeSH:
Cell Hypoxia;
Humans;
Hypoxia;
Hypoxia-Inducible Factor 1, alpha Subunit;
physiology;
Membrane Transport Proteins;
physiology;
MicroRNAs;
physiology;
Pharmaceutical Preparations;
metabolism
- From:
Acta Physiologica Sinica
2019;71(2):336-342
- CountryChina
- Language:Chinese
-
Abstract:
Drug metabolism is significantly affected under hypoxia environment with changes of pharmacokinetics, expression and function of drug-metabolizing enzymes and transporters. Studies have shown that hypoxia increases the release of a series of inflammatory cytokines which can modulate drug metabolism. Besides, both hypoxia inducible factor 1α (HIF-1α) and microRNA-mediated pathways play a role in regulating drug metabolism. This article reviewed the impact and single-factor modulating mechanisms of drug metabolism under hypoxia, and put forward the speculation and prospects of multi-factor modulating mechanisms.
