Facilitative glucose transporters: expression, distribution and the relationship to diseases.
- Author:
Lan-Lan WEI
1
;
Xu REN
2
;
Yan-Yan ZHAO
1
;
Li WANG
2
;
Yu-Feng ZHAO
3
Author Information
1. Institute of Basic Medical Sciences, Xi'an Medical University, Xi'an 710021, China.
2. Department of Nephrology, The Second Affiliated Hospital of Medical School, Xi'an Jiao Tong University, Xi'an 710004, China.
3. Institute of Basic Medical Sciences, Xi'an Medical University, Xi'an 710021, China. yufeng.zhao@xiyi.edu.cn.
- Publication Type:Journal Article
- MeSH:
Biological Transport;
Disease;
Energy Metabolism;
Glucose;
Glucose Transport Proteins, Facilitative;
physiology;
Humans
- From:
Acta Physiologica Sinica
2019;71(2):350-360
- CountryChina
- Language:Chinese
-
Abstract:
Facilitative glucose transporters (GLUT) are proteins that mediate glucose transmembrane transport in the form of facilitated diffusion, which play an important role in regulating cell energy metabolism. There are many breakthroughs in researches of facilitative GLUT in recent years. It has been known that there are 14 subtypes of facilitative GLUT with obvious tissue specificity in distribution and physiological function. In the present review, the tissue and cellular distribution, subcellular localization, expression regulation, physiological function and the relationship to diseases of facilitative GLUT subtypes were summarized, in order to further understand their physiological and pathophysiological significances.
